FIGURE

Fig. 9

ID

ZDB-FIG-080604-21

Publication

Reichenbach et al., 2008 - Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish

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Fig. 9

Transplanted wild type endoderm rescues the enteric ganglia in syu mutants. (A–D) Cross-sections taken through 72 hpf embryos. (E, F) ventral views with anterior to the left of 72 hpf embryos. In wild type embryos phox2b expressing enteric neurons are located on the lateral edge of the gut tube (A). No phox2b expressing cells are found around the gut of syu mutant embryos (B). Transplanted sox32 injected cells are recruited to the endoderm of syu mutants and rescue the enteric ganglia formation (C–E). Endodermal transplants from sox32 injected wild type embryos are not able to rescue enteric ganglia formation in smu mutants (F). Black arrows indicate to phox2b expressing enteric neurons (A, C, D, E); white arrows point to transplanted endoderm (C–F).

Expression Data

Gene:	phox2bb
Fish:	WT shha^tq252/tq252
Anatomical Term:	enteric nervous system
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 318(1), Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T., Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish, 52-64, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.