FIGURE

Fig. 5

ID

ZDB-FIG-080502-10

Publication

Sanek et al., 2008 - A novel role for zebrafish zic2a during forebrain development

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Fig. 5

Zic2a promotes PT formation in cooperation with components of the hedgehog signaling pathway. Embryos of different genetic backgrounds were injected with a conMO (A, C, E) or a zic2aMO (B, D, F) and stained for dlx2a expression by ISH at the prim-5 stage. (A, B) Wild type embryos depleted of Zic2a (B) show a typical reduction of PT relative to control morphants (A). (C) Homozygous syu^t4 mutant embryos show reduction of PT dlx2a (9/35 embryos, 2 exp.). (D) syu^t4 mutants depleted of Zic2a exhibit an almost complete loss of dlx2a in the PT (17/74 embryos, 3 exp.). (E) homozygous smo^b641 embryos show reduced dlx2a expression in the PT (25/83 embryos, 3 exp.). (F) smo^b641 mutants depleted of Zic2a show complete loss of dlx2a in the PT (60/195 embryos, 4 exp.). Embryos are shown in lateral view, anterior to the left. Arrows point to the PT.

Expression Data

Gene:	dlx2a
Fish:	Df(Chr07)t4/t4 AB Df(Chr07)t4/t4 + MO3-zic2a smo^b641/b641 AB + MO3-zic2a smo^b641/b641 + MO3-zic2a
Knockdown Reagent:	MO3-zic2a
Anatomical Terms:	telencephalon ventral thalamus
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr07)t4/t4 + MO3-zic2a AB + MO3-zic2a smo^b641/b641 + MO3-zic2a
Knockdown Reagent:	MO3-zic2a
Observed In:	diencephalon development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(1), Sanek, N.A., and Grinblat, Y., A novel role for zebrafish zic2a during forebrain development, 325-335, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.