FIGURE

Fig. 2

ID

ZDB-FIG-080325-75

Publication

Bessa et al., 2008 - meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye

Other Figures

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Fig. 2

meis1 is required for the growth of the eye primordium. (A,B) Lateral views of representative 72hpf control-MO (A) and meis1-MO (B) -injected fish. meis1 morphants are microphthalmic. (C,D) Confocal images of dissected eyes stained for propidium iodide (nuclei), rhodamine-phalloidin (filamentous actin) and Islet1, which labels GCL nuclei and some in the INL. The reduced eyes from meis1 morphants show apparently normal retina lamination (D,D′), but fewer cells than control eyes (C,C'). Area (E) and estimated volume (F) of control-MO and meis1-MO-injected embryos at 72hpf. meis1- morphant embryos show a significant (P<0.001) reduction in eye area and volume (45% and 60%, respectively). n=20 for each condition.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-meis1b
Knockdown Reagent:	MO1-meis1b
Observed In:	eye
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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