FIGURE

Fig. 4

ID

ZDB-FIG-070823-41

Publication

Xiong et al., 2006 - Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity

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Fig. 4

Genetic Interaction between tob1a and β-Catenin Activity in Zebrafish Embryos Injection doses: 5 pg for β-catΔN mRNA, 100 pg for tob1a mRNA, and 15 ng for tob1a-MO. (A) Morphology of live embryos at the 5-somite stage. (B) Expression of the marker genes (indicated on the top) at the indicated stages (bottom). Orientations of embryos: animal pole views with dorsal oriented toward the right for chordin and eve1; dorsoanterior views for otx2; dorsal views with the animal pole oriented toward the top for ntl; and lateral views with dorsal oriented toward the right for bmp2 and gata2. (C and D) Statistical data for (A) and (B), respectively. (E) The ratios of embryos with duplicated axes that were recognized by morphological observation at the 5-somite stage or molecular examinations.

Expression Data

Genes:	bmp2b chrd eve1 gata2a otx2b tbxta
Fish:	TU
Anatomical Terms:	neuroectoderm notochord shield whole organism
Stage Range:	Shield to Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 11(2), Xiong, B., Rui, Y., Zhang, M., Shi, K., Jia, S., Tian, T., Yin, K., Huang, H., Lin, S., Zhao, X., Chen, Y., Chen, Y.G., Lin, S.C., and Meng, A., Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity, 225-238, Copyright (2006) with permission from Elsevier. Full text @ Dev. Cell