FIGURE

Fig. 5

ID

ZDB-FIG-070815-9

Publication

Auman et al., 2007 - Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Regionalization of nppa Expression in wea, haf, and wea;haf Mutants Is Normal at LHT Stages but Abnormal at Expanded Chamber Stages. Whole-mount in situ hybridization of nppa (A–D and I–L) compared to cmlc2 (E–H and M–P). (A–H) Dorsal views, ventricle to the top, at LHT stages. (A, B, E, and F) are 28 hpf; (C, D, G, and H) are 30 hpf. Although initiation of nppa expression is delayed in haf (C) and wea;haf (D) mutants, the nppa expression domain is normal in the wea (B), haf (C), and wea;haf (D) LHT. (I–P) Frontal views, ventricle to the left, at expanded chamber stages (52 hpf). (J) Regionalized nppa expression is not maintained in the wea mutant ventricle; instead, nppa expression in the wea ventricle is fainter and in a smaller domain than in wild type (wt) (I). (K) In the haf mutant ventricle, intense nppa expression is found throughout the chamber, rather than being restricted to the OC. (L) The wea;haf double mutant ventricle exhibits weak and diffuse nppa expression.

Expression Data

Genes:	myl7 nppa
Fish:	WT myh6^m58/m58 myh7^sk24/sk24 myh7^sk24/sk24; myh6^m58/m58
Anatomical Terms:	atrium cardiac ventricle heart tube
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myh6^m58/m58 myh7^sk24/sk24 myh7^sk24/sk24; myh6^m58/m58
Observed In:	cardiac ventricle
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.