FIGURE

Fig. 6

ID

ZDB-FIG-070628-5

Publication

Lin et al., 2007 - Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis

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Fig. 6

Reduction of Med10 does not affect FGF or BMP signaling. MO1-Med10 (10 ng) was injected into embryos at the one-cell stage. Embryos were fixed at 50% epiboly and stained using in situ hybridization. Animal views are shown. (A–D) Reduction of Med10 has no effect on FGF-regulated gene expression, as manifested by sprouty and spadetail (spt) staining in med10 morphants (B,D) and control embryos (A,C). (E–H) Reduction of Med10 has no effect on the expression of BMP target genes as manifested by in situ hybridization staining for vent and vox (F,H), as compared to uninjected control embryos (E,G). Shown are animal pole views with dorsal to the right.

Expression Data

Genes:	spry2 tbx16 vent vox
Fish:	WT WT + MO1-med10
Knockdown Reagent:	MO1-med10
Anatomical Terms:	margin presumptive mesoderm
Stage:	50%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 303(2), Lin, X., Rinaldo, L., Fazly, A.F., and Xu, X., Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis, 536-548, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.