FIGURE

Fig. 2

ID

ZDB-FIG-070413-5

Publication

Hsiao et al., 2007 - A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes

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Fig. 2

Number of Epidermal Ionocyte Progenitors is Restricted by Delta-Notch-Mediated Lateral Inhibition. (A–C) Dynamic expression of the epidermal ionocyte progenitor marker of foxi3a (black, cytoplasmic staining) and the epidermal stem cell marker of P63 (green, nuclear staining) on the zebrafish epidermis. In the beginning, foxi3a was activated in some P63-positive epidermal stem cells at the tail bud (tb) stage (indicated by asterisks, A). However, as development precedes, P63 expression in epidermal ionocyte progenitors is sharply downregulated (at the 14-somite (14-s) stage, B) ultimately to an undetectable level (24 hour post infection (hpf), C). (D–I) The mosaic distribution of epidermal ionocyte progenitors within the epidermal ionocyte domain is controlled by Delta-Notch-mediated lateral inhibition. In DAPT-treated embryos (F), and mib^ta52b- (G) or X-Su(H)^DBM mRNA-injected embryos (H), the foxi3a expression in the epidermal ionocyte domain has become denser and more homogeneous. While in X-Su(H)/Ank mRNA-injected embryos (I), foxi3a expression in the epidermal ionocyte domain is greatly reduced. The developmental stage is indicated in the left lower corner of each panel.

Expression Data

Gene:	foxi3a
Fish:	AB mib1^ta52b/ta52b
Condition:	chemical treatment: DAPT
Anatomical Terms:	ectoderm epidermis
Stage Range:	Bud to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^ta52b/ta52b
Observed In:	ectoderm development
Stage:	Bud

Phenotype Detail

Acknowledgments

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