FIGURE

Fig. 4

ID

ZDB-FIG-061226-29

Publication

Montero-Balaguer et al., 2006 - The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish

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Fig. 4

Pigment cell progenitors show deficits in the mos^m188 mutants. Expression analysis of pigment specific genes in wild type (A, C, E, G) lateral and (A', C', E', G') dorsal views, and in mos^m188 mutants (B, D, F, H) lateral and (B', D', F', H') dorsal views as revealed by whole mount in situ hybridization in 22 hpf embryos. A-B': Expression of mitfa/nac, the early marker of pigment progenitors, is significantly downregulated in the trunk region while the mid-hindbrain boundary domain is unaffected in mos^m188 mutants. C-D': Similarly, the melanophores specific dct/trp2 expression is largely absent in mos^m188 mutants at this stage. E-F':Fms that specifies melanophore and xanthophore lineages is essentially absent in mos^m188mutants as is xanthine dehydrogenase (G-H';), the enzyme in pteridine synthesis pathway that marks lineage-committed xanthoblasts.

Expression Data

Genes:	aox5 csf1ra dct mitfa
Fish:	WT foxd3^m188 (AB)
Anatomical Term:	pigment cell
Stage:	26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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