FIGURE

Fig. 2

ID

ZDB-FIG-061121-29

Publication

Kopinke et al., 2006 - Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification

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Fig. 2

Developmental defects observed in live embryos at 30 hpf when RA signaling is impaired. A: Untreated 30-hpf embryo. B: Embryos that were exposed to DEAB during gastrulation from sphere stage (4 hpf) to tailbud stage (10 hpf) show a reduction of the distance between otic vesicle (arrow) and first somite (asterisk) and a kink dorsal to the otic vesicle (arrowhead). Furthermore, the otic vesicle is smaller and only one otholith has formed. C: Embryos treated with DEAB post-gastrulation between 16-30 hpf show aberrant otic vesicle development and heart defects at 30 hpf. ov, otic vesicle; som, somites. Lateral views, anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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