FIGURE

Fig. 2

ID

ZDB-FIG-060808-223

Publication

Peng et al., 2006 - Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists

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Fig. 2

Lhx5 partially rescues forebrain deficiencies induced by ectopic Wnt signaling. (A) lhx5 gain of function partially rescues the eyeless phenotype of wnt8a mRNA-injected embryos. Injected embryos were scored after the Prim-5 stage (24 hours post-fertilization). The percentages of embryos eyeless (blue) or with two eyes (green), or malformed as a result of dorsalization or injection (yellow), were measured. (B-D) lhx5 gain of function partially rescues eye development in mbl (axin1) mutants. Ventral views, rostral to the left. (E-G) lhx5 gain of function partially restores emx3 expression in mbl (axin1) mutants. Genotypes of mutant and partially rescued embryos were verified by RFLP. (H-J) lhx5 gain of function partially restores six3b expression in mbl (axin1) mutants. WT, wild-type embryos. Scale bar in J: 150 μm for B-D; 250 μm for E-J.

Expression Data

Genes:	emx3 six3b
Fish:	WT axin1^tm213/tm213
Anatomical Term:	neural keel
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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