FIGURE

Fig. 4

ID

ZDB-FIG-051027-1

Publication

Sheela et al., 2005 - Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization

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Fig. 4

Expression domain of ff1a in slow muscle is modulated by components of the Hedgehog signaling pathway. (A–F) Lateral view with the anterior to the left. (A) The expression domain of ff1a in the somites at 15 hpf. (B) Misexpression of mouse Shh RNA led to the expansion of the expression domain of ff1a. (C) ff1a expression is down-regulated in the trunk somites at 24 hpf, (D) ff1a RNA is retained in Shh overexpressed embryos. (E) Weak ff1a expression could be seen in control embryo at 20 hpf, (F) whereas in forskolin-treated embryos, ff1a expression is abolished in the somites. (G–J) Cross-sections of the embryos in panels (A, B) are shown in panels (G, H), respectively. Expression domain of ff1a in the somites at 18 hpf (I) was expanded in embryos where PKI was overexpressed (J).

Expression Data

Gene:	nr5a2
Fish:	AB
Condition:	chemical treatment: forskolin
Anatomical Term:	somite
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 286(2), Sheela, S.G., Lee, W.C., Lin, W.W., and Chung, B.C., Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization, 377-390, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.