FIGURE

Fig. 1

ID

ZDB-FIG-050930-9

Publication

Babb et al., 2005 - Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation

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Fig. 1

Cdh4 knockdown affects eye size, body length, and brain morphology. A-H: Zebrafish embryos were injected (1-2 nl at 0.5 mM) with either standard control morpholino oligonucleotide (MO, A,B) or cdh4 MO (C-H). These injections produced a hypomorphic series of effects. At 2 days postfertilization (dpf), living embryos were imaged using a stereo-dissecting microscope (A,C,E,G) or by differential interference contrast microscopy (B,D,F,H). A-H: The cdh4 morphants (C-H) were micro-ophthalmic, had small lenses, lacked retinal lamination, had perturbed brain organization and shorter body length compared with controls (A,B). D,F,H: The fourth ventricle (IV) was enlarged and the hindbrain (hb) was reduced in cdh4 morphants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cdh4 WT + MO2-cdh4
Knockdown Reagents:	MO1-cdh4 MO2-cdh4
Observed In:	brain eye fourth ventricle hindbrain lens retina layer formation whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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