FIGURE

Fig. 2

ID

ZDB-FIG-050607-8

Publication

Thorpe et al., 2005 - Wnt/β-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish

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Fig. 2

wnt3a and wnt8 are required for the maintenance, not initiation, of tailbud marker expression. (A-L) Embryos injected with the indicated morpholinos were fixed at tailbud stage and stained for ntl (A-D), fgf8 (E-H) and tbx6 (I-L). Embryos are shown in dorsal views, anterior to the top. (M-B') Injected embryos were allowed to develop until the 5-somite stage (M-P) or 10-somite stage (Q-B') and stained for tbx6 (M-T), spt (U-X) or ppt (Y-B'). All embryos are flat mounted and shown in dorsal views with anterior to the top. By the 10-somite stage in the tailbud of wnt3a/wnt8 MO embryos, tbx6 (T) and spt (X) are not expressed, while ppt (B') is still expressed at reduced levels compared with wnt3a MO (Z) or wnt8 MO (A').

Expression Data

Genes:	fgf8a tbx16 tbx16l tbxta wnt5b
Fish:	AB AB + MO1-wnt3a AB + MO1-wnt8a + MO2-wnt8a AB + MO1-wnt3a + MO1-wnt8a + MO2-wnt8a
Knockdown Reagents:	MO1-wnt3a MO1-wnt8a MO2-wnt8a
Anatomical Term:	unspecified
Stage Range:	Bud to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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