ZFIN All Figures, Xu <i>et al.</i>, 2015

Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Gene:	tp53
Antibody:	Ab7-tp53
Fish:	WT WT + MO1-smc3 WT + MO2-rad21a
Knockdown Reagents:	MO1-smc3 MO2-rad21a
Anatomical Term:	whole organism
Stage:	Prim-5

Expression / Labeling details

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	eye head heart post-vent region whole organism
Stage Range:	Prim-5 to Day 5

Phenotype details

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a rad21a^hi2529Tg smc1al^hi1113aTg WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	eye head post-vent region trunk whole organism
Stage:	Protruding-mouth

Phenotype details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	translation
Stage:	Prim-5

Phenotype details

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	rRNA transcription translation
Stage:	Prim-5

Phenotype details

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a rad21a^hi2529Tg smc1al^hi1113aTg WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	cranial cartilage cartilage development
Stage:	Day 5

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	head apoptotic process post-vent region apoptotic process
Stage:	Long-pec

Phenotype details

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO2-rad21a
Observed In:	cell population proliferation
Stage:	Prim-5

Phenotype details

Fig. 8

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: 4-methyl-2-oxopentanoic acid
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO2-rad21a
Observed In:	embryo development eye head whole organism
Stage Range:	Day 4 to Day 5

Phenotype details

Fig. 9

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: 4-methyl-2-oxopentanoic acid
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO2-rad21a
Observed In:	rRNA transcription translation
Stage:	Prim-5

Phenotype details

Fig. S4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO1-smc3 WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO1-smc3 MO2-rad21a
Observed In:	whole organism
Stage:	Day 5

Phenotype details

Fig. S7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT + MO2-rad21a WT + MO1-nipbla + MO1-nipblb
Condition:	chemical treatment: L-leucine zwitterion
Knockdown Reagents:	MO1-nipbla MO1-nipblb MO2-rad21a
Observed In:	heart heart contraction
Stage:	Day 5

Phenotype details

Acknowledgments

Full text @ Hum. Mol. Genet.

Xu et al., 2015

ZDB-PUB-141108-5
PMID:25378554

L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome

Xu et al., 2015 ZDB-PUB-141108-5 PMID:25378554

L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome

Xu et al., 2015

ZDB-PUB-141108-5
PMID:25378554