necroptotic process

Term ID

GO:0070266

Synonyms

• activation of necroptosis
• activation of necroptosis by extracellular signals
• activation of necroptosis in response to extracellular signals
• activation of necroptosis of activated-T cells
• establishment of necroptosis
• establishment of necroptosis of activated-T cells
• extracellular signal-induced necroptosis
• induction of necroptosis
• induction of necroptosis by extracellular signals
• induction of necroptosis of activated-T cells
• necroptosis
• PARP-dependent cell death
• parthanatos
• programmed necrosis
• programmed necrotic cell death
• RIPK1-mediated regulated necrosis
• TNF-induced necroptosis

Definition

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. (5)

References

• Reactome:R-HSA-5213460

Ontology

GO: Biological Process    QuickGO    AmiGO