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ChEBI

irinotecan hydrochloride hydrate

Term ID
CHEBI:90881
Synonyms
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride--water (1/3)
  • 1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride--water (1/3)
  • Camptosar
  • CPT 11
  • CPT-11
  • Irinotecan hydrochloride
  • irinotecan hydrochloride trihydrate
  • irinotecan monohydrochloride trihydrate
  • ONIVYDE
  • U-101,440E
Definition
A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
Phenotype
Phenotype resulting from irinotecan hydrochloride hydrate
Phenotype where environments contain irinotecan hydrochloride hydrate
Phenotype modified by environments containing irinotecan hydrochloride hydrate
Human Disease / Model Data