irinotecan hydrochloride (anhydrous)

Term ID

CHEBI:5971

Synonyms

(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride
1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium chloride
7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxy camptothecin hydrochloride
Camptothecin 11 hydrochloride
CPT 11
CPT-11
Irinotecan HCl
Irinotecan hydrochloride
irinotecan monohydrochloride
U 101440E

Definition

A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: irinotecan(1+)

irinotecan(1+) Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug

antineoplastic agent apoptosis inducer EC 5.99.1.2 (DNA topoisomerase) inhibitor prodrug Show first 5 Terms
inverse has_part: irinotecan hydrochloride hydrate

irinotecan hydrochloride hydrate Show first 5 Terms

Phenotype

Phenotype resulting from irinotecan hydrochloride (anhydrous)

Phenotype where environments contain irinotecan hydrochloride (anhydrous)

Phenotype modified by environments containing irinotecan hydrochloride (anhydrous)

Human Disease Model