celastrol

Term ID

CHEBI:63959

Synonyms

• (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid
• (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
• D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-
• Tripterine

Definition

A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

References

• CAS:34157-83-0
• HMDB:HMDB0002385
• PMID:11809076
• PMID:15593077
• PMID:20934245
• PMID:20954803
• PMID:21134410
• PMID:21414301
• PMID:21425580
• PMID:21466843
• PMID:21569548
• PMID:21666907
• PMID:21850367
• PMID:21865725
• PMID:21866552
• PMID:22087583
• PMID:22206928
• PMID:22334592
• Patent:KR20100097843
• Patent:US2011263693
• Reaxys:2194425

Ontology

ChEBI  ( EBI )