Search Ontology:
ChEBI

dutasteride

Term ID
CHEBI:521033
Synonyms
  • (5alpha,17beta)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
  • N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
Definition
An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.
References
  • Beilstein:7401530
  • CAS:164656-23-9
  • DrugBank:DB01126
  • Drug_Central:973
  • KEGG:D03820
  • Patent:WO9507927
  • Wikipedia:Dutasteride
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_parent_hydride
has_role
Phenotype
Phenotype resulting from dutasteride
Phenotype where environments contain dutasteride
Phenotype modified by environments containing dutasteride
Human Disease Model