entecavir (anhydrous)

Term ID

CHEBI:473990

Synonyms

• 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
• entecavir

Definition

Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.

References

• Beilstein:7692760
• CAS:142217-69-4
• DrugBank:DB00442
• Drug_Central:1019
• KEGG:D07896
• LINCS:LSM-5258

Ontology

ChEBI  ( EBI )