mycophenolic acid

Term ID

CHEBI:168396

Synonyms

• (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
• (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
• acide mycophenolique
• acido micofenolico
• acidum mycophenolicum
• Micofenolico acido
• Mycophenolate
• mycophenolic acid
• Mycophenolsaeure

Definition

A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

References

• Beilstein:318158
• CAS:24280-93-1
• DrugBank:DB01024
• Drug_Central:1860
• KEGG:D05096
• PDBeChem:MOA
• PMID:11272311
• PMID:15470161
• PMID:16629948
• PMID:16640327
• PMID:17482154
• PMID:17498396
• PMID:18194117
• PMID:18611107
• PMID:18996104
• PMID:19689217
• Patent:US4753935
• Reaxys:318158
• Wikipedia:Mycophenolic_acid

Ontology

ChEBI  ( EBI )

Resources

CTD