PD-166866

Term ID

CHEBI:156259

Synonyms

1-[2-amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea
PD 166866
PD-166866
PD166866

Definition

A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: biaryl dimethoxybenzene primary arylamine pyridopyrimidine ureas

biaryl dimethoxybenzene primary arylamine pyridopyrimidine ureas Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms
inverse has_functional_parent: PD173074

PD173074 Show first 5 Terms

Phenotype

Phenotype resulting from PD-166866

Phenotype where environments contain PD-166866

Phenotype modified by environments containing PD-166866

Human Disease Model