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Phenotype Figure Summary
Marker:
dmxl2
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Tuttle
et al.
, 2014
Fig. 2
ir937Tg + MO1-dmxl2 + MO1-tp53
, 
WT + MO1-dmxl2 + MO1-tp53
, 
dmxl2
t21192/t21192
melanoblast neural crest cell aggregated, abnormal
midbrain hindbrain boundary morphology, abnormal
neural crest cell migration decreased rate, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell migration process quality, abnormal
neural crest cell mislocalised, abnormal
post-vent region decreased length, abnormal
post-vent region kinked, abnormal
xanthoblast neural crest cell aggregated, abnormal
Fig. 3
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell early endosome aggregated, abnormal
neural crest cell early endosome increased amount, abnormal
neural crest cell early endosome increased size, abnormal
neural crest cell endocytosis process quality, abnormal
neural crest cell endosome immature, abnormal
neural crest cell late endosome decreased amount, abnormal
neural crest cell late endosome decreased size, abnormal
Fig. 5
WT + MO1-dmxl2 + MO1-tp53
canonical Wnt signaling pathway decreased process quality, abnormal
Fig. S1
WT + MO1-dmxl2 + MO1-tp53
, 
dmxl2
t21192/t21192
melanocyte decreased amount, abnormal
pericardium edematous, abnormal
post-vent region curved, abnormal
post-vent region decreased length, abnormal
Fig. S2
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell aggregated, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell mislocalised, abnormal
Fig. S3
ir937Tg + MO1-dmxl2 + MO1-tp53
, 
ir937Tg + MO1-tp53 + MO2-dmxl2
neural crest cell aggregated, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell mislocalised, abnormal
Fig. S5
WT + MO1-dmxl2 + MO1-tp53
neural crest cell migration decreased rate, abnormal
Fig. S6
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell early endosome increased amount, abnormal
neural crest cell early endosome increased size, abnormal
Einhorn
et al.
, 2012
Fig. 1
dmxl2
t21010/t21010
, 
dmxl2
t26173/t26173
, 
dmxl2
t21192/t21192
sensory perception of sound decreased process quality, abnormal
Fig. 3
dmxl2
t26173/t26173
, 
dmxl2
t21192/t21192
neuromast hair cell synaptic vesicle lumen decreased acidity, abnormal
regulation of cellular pH reduction decreased process quality, abnormal
regulation of proton-transporting ATPase activity, rotational mechanism decreased process quality, abnormal
synaptic vesicle lumen acidification decreased process quality, abnormal
synaptic vesicle maturation decreased process quality, abnormal
Fig. 4
dmxl2
t21192/t21192
neuromast hair cell vacuolar proton-transporting V-type ATPase, V1 domain mislocalised, abnormal
Fig. 6
dmxl2
t21192/t21192
neuron-neuron synaptic transmission decreased process quality, abnormal
sensory perception of sound decreased process quality, abnormal
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