Publication	Data		Fish	Anatomy
Zareba et al., 2024	Fig. 1		i149Tg/i149Tg; i186Tg/i186Tg + CRISPR1-npc2.1 + CRISPR2-npc2.1 ,   zh901Tg/zh901Tg + CRISPR1-npc2.1 + CRISPR2-npc2.1	microglial cell cell projection decreased amount, abnormal optic tectum microglial cell circular, abnormal optic tectum microglial cell mCherry expression spatial pattern, abnormal
	Fig. 2		i149Tg/i149Tg; i186Tg/i186Tg + CRISPR1-npc2.1 + CRISPR2-npc2.1	hindbrain microglial cell mCherry expression spatial pattern, abnormal optic tectum phagocytic vesicle increased size, abnormal
Tseng et al., 2021	Fig. 10		npc2.1y536/y536 (EKW)	brain msx3 expression decreased amount, abnormal brain notch3 expression decreased amount, abnormal otic vesicle msx3 expression decreased amount, abnormal otic vesicle notch3 expression decreased amount, abnormal trunk dorsal margin msx3 expression decreased amount, abnormal
	Fig. 3		npc2.1y536/y536 (EKW)	neuromast lysosome increased amount, abnormal peripheral olfactory organ lysosome increased amount, abnormal trunk cholesterol increased amount, abnormal
	Fig. 4		npc2.1y536/y536 (EKW)	post-vent region curved dorsal, abnormal swim bladder uninflated, abnormal vertebral column increased curvature, abnormal vertebral column kinked, abnormal whole organism decreased length, abnormal
	Fig. 5		npc2.1y536/y536 (EKW)	blood circulation disrupted, abnormal brain decreased size, abnormal head decreased size, abnormal hindbrain decreased size, abnormal otic vesicle disorganized, abnormal otolith absent, abnormal post-vent region curved dorsal, abnormal post-vent region curved lateral, abnormal post-vent region curved ventral, abnormal post-vent region kinked, abnormal yolk syncytial layer cholesterol increased amount, abnormal
	Fig. 6		npc2.1y536/y536 (EKW)	blood circulation disrupted, abnormal brain decreased size, abnormal head decreased size, abnormal otolith absent, abnormal post-vent region curved dorsal, abnormal post-vent region curved lateral, abnormal post-vent region curved ventral, abnormal post-vent region kinked, abnormal
	Fig. S5		npc2.1y536/y536 (EKW)	vertebral column increased curvature, abnormal vertebral column kinked, abnormal
	Fig. S7		npc2.1y536/y536 (EKW)	hindbrain multivesicular body increased amount, abnormal otic vesicle cytoplasm decreased volume, abnormal
	Fig. S8		npc2.1y536/y536 (EKW)	central nervous system nkx2.2a expression decreased amount, abnormal Rohon-Beard neuron axon decreased amount, abnormal
Wiweger et al., 2021	FIGURE 1		npc2.1waw302/waw302 (TL)	gonad npc2.1 expression decreased amount, abnormal heart npc2.1 expression decreased amount, abnormal liver npc2.1 expression decreased amount, abnormal spleen npc2.1 expression decreased amount, abnormal whole organism decreased length, abnormal whole organism decreased weight, abnormal
	FIGURE 10		npc2.1waw302/waw302 (TL)	whole organism apoea expression decreased amount, abnormal whole organism capn2a expression decreased amount, abnormal whole organism lgals3a expression decreased amount, abnormal whole organism mcu expression decreased amount, abnormal whole organism mpeg1.1 expression decreased amount, abnormal whole organism ppp3ca expression decreased amount, abnormal
	FIGURE 2		npc2.1waw302/waw302 (TL)	peripheral olfactory organ increased accumulation peripheral olfactory organ nile blue A, abnormal
	FIGURE 3		npc2.1waw302/waw302 (TL)	peripheral olfactory organ increased accumulation peripheral olfactory organ nile blue A, abnormal
	FIGURE 4		npc2.1waw302/waw302 (TL)	whole organism locomotory behavior decreased process quality, abnormal whole organism thigmotaxis increased process quality, abnormal
	FIGURE 5		npc2.1waw302/waw302 (TL)	hepatocyte increased accumulation hepatocyte lipid droplet, abnormal hepatocyte nucleus increased size, abnormal kidney cell degeneration, abnormal pancreatic acinar cell cholesterol increased amount, abnormal pancreatic acinar cell inclusion body increased amount, abnormal pancreatic acinar cell zymogen granule absent, abnormal
	FIGURE 6		npc2.1waw302/waw302 (TL)	cerebellum Purkinje cell distributed, abnormal fasciculus retroflexus vacuolated, abnormal habenula structure, abnormal habenula vacuolated, abnormal habenular commissure myelination decreased process quality, abnormal interpeduncular nucleus tegmentum vacuolated, abnormal lateral longitudinal fasciculus degeneration, abnormal medial longitudinal fasciculus degeneration, abnormal midbrain myelination decreased process quality, abnormal midbrain vacuolated, abnormal raphe nucleus vacuolated, abnormal
	FIGURE 7		npc2.1waw302/waw302 (TL)	cerebellum Purkinje cell distributed, abnormal cerebellum Purkinje cell structure, abnormal cranial nerve I degeneration, abnormal cranial nerve II vacuolated, abnormal hindbrain degeneration, abnormal olfactory bulb vacuolated, abnormal optic tectum vacuolated, abnormal telencephalon vacuolated, abnormal
	FIGURE 8		npc2.1waw302/waw302 (TL)	brain mbpa expression decreased amount, abnormal brain mpz expression decreased amount, abnormal brain myelination decreased process quality, abnormal whole organism cldnk expression decreased amount, abnormal whole organism mbpa expression decreased amount, abnormal whole organism olig1 expression decreased amount, abnormal whole organism plp1b expression decreased amount, abnormal whole organism myelination decreased process quality, abnormal
	FIGURE 9		npc2.1waw302/waw302 (TL)	brain capn2a expression increased amount, abnormal brain il1b expression increased amount, abnormal brain mpeg1.1 expression increased amount, abnormal brain nfkb2 expression increased amount, abnormal brain calcium ion homeostasis process quality, abnormal brain inflammatory response increased process quality, abnormal liver apoea expression increased amount, abnormal liver il1b expression increased amount, abnormal liver mpx expression increased amount, abnormal liver ppp3ca expression increased amount, abnormal liver calcium ion homeostasis process quality, abnormal liver inflammatory response increased process quality, abnormal