| ZFIN ID: ZDB-EXP-180307-6 |
Experiment Conditions Description: high cholesterol, chemical treatment by diet: lomitapide
| high cholesterol |
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| Name: | high cholesterol |
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| Synonyms: | |
| Definition: | Cholesterol content condition in which the amount of cholesterol in the diet is elevated. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000119] |
| chemical treatment by diet: lomitapide |
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| Name: | chemical treatment by diet |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the diet. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000239] |
| Name: | lomitapide |
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| Synonyms: | AEGR 733, AEGR 773, AEGR-773, AEGR733, AEGR773, BMS 201038, BMS201038, Lojuxta, lomitapida, lomitapide, lomitapidum, N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide |
| Definition: | A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. |
| Ontology: | ChEBI [CHEBI:72297] ( EBI ) |
| Publication: | Liu et al., 2017 |
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