| ZFIN ID: ZDB-EXP-151118-1 |
Experiment Conditions Description: chemical treatment: WIN 18446
| chemical treatment: WIN 18446 |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | WIN 18446 |
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| Synonyms: | Fertilysin, Fertilysine, N,N'-1,8-Octanediylbis(2,2-dichloroacetamide), N,N'-bis(dichloracetyl)-1,8-octanediamine, N,N'-bis(dichloroacetyl)-1,8-diaminooctane, N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine, N,N'-octamethylenebis(2,2-dichloro-N-ethylacetamide), N,N'-octamethylenebis(2,2-dichloroacetamide), N,N'-octane-1,8-diylbis(2,2-dichloroacetamide), WIN 18,446, Win-18446, WIN18446 |
| Definition: | A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish. |
| Ontology: | ChEBI [CHEBI:90441] ( EBI ) |
| Publication: | Pradhan et al., 2015 |
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