WIN 18446

Term ID

CHEBI:90441

Synonyms

• Fertilysin
• Fertilysine
• N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
• N,N'-bis(dichloracetyl)-1,8-octanediamine
• N,N'-bis(dichloroacetyl)-1,8-diaminooctane
• N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine
• N,N'-octamethylenebis(2,2-dichloro-N-ethylacetamide)
• N,N'-octamethylenebis(2,2-dichloroacetamide)
• N,N'-octane-1,8-diylbis(2,2-dichloroacetamide)
• WIN 18,446
• Win-18446
• WIN18446

Definition

A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish.

References

• CAS:1477-57-2
• PMID:14599310
• PMID:3970137
• PMID:6260633
• PMID:8563190
• Patent:US3143566
• Reaxys:2136774

Ontology

ChEBI  ( EBI )

Resources

CTD