| ZFIN ID: ZDB-EXP-071017-11 |
Experiment Conditions Description: chemical treatment: SU4312
| chemical treatment: SU4312 |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | SU4312 |
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| Synonyms: | 3-(4-dimethylamino-benzylidenyl)-2-indolinone, 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one, 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one, DMBI, SU 4312, SU-4312 |
| Definition: | A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. |
| Ontology: | ChEBI [CHEBI:92369] ( EBI ) |
| Publication: | Molina et al., 2007 |
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