Search Ontology:
ChEBI

SU4312

Term ID
CHEBI:92369
Synonyms
  • 3-(4-dimethylamino-benzylidenyl)-2-indolinone
  • 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
  • 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
  • DMBI
  • SU 4312
  • SU-4312
Definition
A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from SU4312
Phenotype where environments contain SU4312
Phenotype modified by environments containing SU4312
Human Disease Model
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