PUBLICATION
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
- Authors
- Schauerte, H.E., van Eeden, F.J.M., Fricke, C., Odenthal, J., Strähle, U., Haffter, P.
- ID
- ZDB-PUB-980729-15
- Date
- 1998
- Source
- Development (Cambridge, England) 125: 2983-2993 (Journal)
- Registered Authors
- Fricke, Cornelia, Haffter, Pascal, Odenthal, Joerg, Schauerte, Heike, Strähle, Uwe, van Eeden, Freek
- Keywords
- sonic hedgehog; sonic-you; zebrafish; floor plate; somitogenesis
- MeSH Terms
-
- Embryonic Induction*
- Mutation
- Eye Proteins
- Stem Cells
- RNA Splicing
- DNA-Binding Proteins/biosynthesis
- Genetic Complementation Test
- Repressor Proteins
- Retinal Ganglion Cells
- Nervous System/embryology*
- Zebrafish Proteins
- Transcription Factors/biosynthesis
- Animals
- Sequence Analysis, DNA
- Eye/embryology
- Somites*
- Protein Sorting Signals/genetics
- Proteins/metabolism*
- Body Patterning
- Nervous System Malformations
- Axons
- Hedgehog Proteins
- Muscles/cytology
- PAX2 Transcription Factor
- Cyclic AMP-Dependent Protein Kinases/metabolism
- Signal Transduction
- Zebrafish/embryology*
- Trans-Activators*
- Homeodomain Proteins/biosynthesis
- Paired Box Transcription Factors
- PubMed
- 9655820 Full text @ Development
Citation
Schauerte, H.E., van Eeden, F.J.M., Fricke, C., Odenthal, J., Strähle, U., Haffter, P. (1998) Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (Cambridge, England). 125:2983-2993.
Abstract
Sonic hedgehog (Shh) is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates. We show that the zebrafish sonic-you (syu) gene, a member of a group of five genes required for somite patterning, is encoding Shh. Embryos mutant for a deletion of syu display defects in patterning of the somites, the lateral floor plate cells, the pectoral fins, the axons of motorneurons and the retinal ganglion cells. In contrast to mouse embryos lacking Shh activity, syu mutant embryos do form medial floor plate cells and motorneurons. Since ectopic overexpression of shh in zebrafish embryos does not induce ectopic medial floor plate cells, we conclude that shh is neither required nor sufficient to induce this cell type in the zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping