PUBLICATION
The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development
- Authors
- Habicher, J., Sanvido, I., Bühler, A., Sartori, S., Piccoli, G., Carl, M.
- ID
- ZDB-PUB-240328-19
- Date
- 2024
- Source
- Genes 15(3): (Other)
- Registered Authors
- Bühler, Anja, Carl, Matthias, Habicher, Judith
- Keywords
- IgLON, brain, negr1, neuropsychiatric disorder, opcml, zebrafish development
- MeSH Terms
-
- Cell Adhesion Molecules/genetics
- Humans
- Immunoglobulins/genetics
- Brain/metabolism
- Mammals/metabolism
- Animals
- GPI-Linked Proteins/metabolism
- Depressive Disorder, Major*
- Zebrafish/genetics
- Zebrafish/metabolism
- Schizophrenia*
- PubMed
- 38540422 Full text @ Genes (Basel)
Citation
Habicher, J., Sanvido, I., Bühler, A., Sartori, S., Piccoli, G., Carl, M. (2024) The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development. Genes. 15(3):.
Abstract
The immunoglobulin LAMP/OBCAM/NTM (IgLON) family of cell adhesion molecules comprises five members known for their involvement in establishing neural circuit connectivity, fine-tuning, and maintenance. Mutations in IgLON genes result in alterations in these processes and can lead to neuropsychiatric disorders. The two IgLON family members NEGR1 and OPCML share common links with several of them, such as schizophrenia, autism, and major depressive disorder. However, the onset and the underlying molecular mechanisms have remained largely unresolved, hampering progress in developing therapies. NEGR1 and OPCML are evolutionarily conserved in teleosts like the zebrafish (Danio rerio), which is excellently suited for disease modelling and large-scale screening for disease-ameliorating compounds. To explore the potential applicability of zebrafish for extending our knowledge on NEGR1- and OPCML-linked disorders and to develop new therapeutic strategies, we investigated the spatio-temporal expression of the two genes during early stages of development. negr1 and opcml are expressed maternally and subsequently in partially distinct domains of conserved brain regions. Other areas of expression in zebrafish have not been reported in mammals to date. Our results indicate that NEGR1 and OPCML may play roles in neural circuit development and function at stages earlier than previously anticipated. A detailed functional analysis of the two genes based on our findings could contribute to understanding the mechanistic basis of related psychiatric disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping