PUBLICATION

The habenula is crucial for experience-dependent modification of fear responses in zebrafish

Authors
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
ID
ZDB-PUB-101018-15
Date
2010
Source
Nature Neuroscience   13(11): 1354-1356 (Journal)
Registered Authors
Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
Keywords
none
MeSH Terms
  • RNA, Messenger/metabolism
  • Fear/physiology*
  • Transcription Factor Brn-3A/genetics
  • Zebrafish/physiology*
  • Adaptation, Physiological/physiology
  • Electroshock/adverse effects
  • Neurons/metabolism
  • Animals
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Behavior, Animal
  • Neural Pathways/physiology
  • Gene Expression Regulation/physiology*
  • Conditioning, Classical/physiology
  • Locomotion/physiology
  • Amino Acids/metabolism
  • HSP72 Heat-Shock Proteins/genetics
  • Analysis of Variance
  • Carbocyanines/metabolism
  • Habenula/cytology
  • Habenula/metabolism
  • Habenula/physiology*
  • Green Fluorescent Proteins/genetics
  • Time Factors
  • In Situ Nick-End Labeling
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Tryptophan Hydroxylase/genetics
  • Tryptophan Hydroxylase/metabolism
  • Animals, Genetically Modified
  • Larva
PubMed
20935642 Full text @ Nat. Neurosci.
Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping