PUBLICATION

The habenula is crucial for experience-dependent modification of fear responses in zebrafish

Authors
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
ID
ZDB-PUB-101018-15
Date
2010
Source
Nature Neuroscience   13(11): 1354-1356 (Journal)
Registered Authors
Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
Keywords
none
MeSH Terms
  • Locomotion/physiology
  • Larva
  • Gene Expression Regulation/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Adaptation, Physiological/physiology
  • Amino Acids/metabolism
  • Analysis of Variance
  • Animals
  • Habenula/cytology
  • Habenula/metabolism
  • Habenula/physiology*
  • In Situ Nick-End Labeling
  • Conditioning, Classical/physiology
  • RNA, Messenger/metabolism
  • Animals, Genetically Modified
  • Tryptophan Hydroxylase/genetics
  • Tryptophan Hydroxylase/metabolism
  • Neural Pathways/physiology
  • Electroshock/adverse effects
  • Neurons/metabolism
  • Behavior, Animal
  • Green Fluorescent Proteins/genetics
  • HSP72 Heat-Shock Proteins/genetics
  • Transcription Factor Brn-3A/genetics
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Fear/physiology*
  • Zebrafish/physiology*
  • Carbocyanines/metabolism
  • Time Factors
PubMed
20935642 Full text @ Nat. Neurosci.
Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping