Person
Aizawa, Hidenori
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Biography and Research Interest
Dr. Aizawa is the Professor of the Department of Neurobiology in Hiroshima University. Following completion of his Ph.D in Chiba University, he joined RIKEN Brain Science Institute as a research scientist as well as deputy lab head and found evolutionarily conserved habenular pathways in vertebrates. After he moved to the Tokyo Medical and Dental University, he primarily works for a role of the habenula in depression using rodents and fish.
Non-Zebrafish Publications
1: Li WR, Nakano T, Mizutani K, Matsubara T, Kawatani M, Mukai Y, Danjo T, Ito
H, Aizawa H, Yamanaka A, Petersen CCH, Yoshimoto J, Yamashita T. Neural
mechanisms underlying uninstructed orofacial movements during reward-based
learning behaviors. Curr Biol. 2023 Aug 21;33(16):3436-3451.e7. doi:
10.1016/j.cub.2023.07.013. Epub 2023 Aug 2. PMID: 37536343.
2: Kasaragod DK, Aizawa H. Deep ultraviolet fluorescence microscopy of three-
dimensional structures in the mouse brain. Sci Rep. 2023 May 26;13(1):8553. doi:
10.1038/s41598-023-35650-2. PMID: 37237102; PMCID: PMC10219975.
3: Kikutani K, Hosokawa K, Giga H, Ota K, Matsumata M, Zhu M, Takemoto H, Ji B,
Ohshimo S, Shime N, Aizawa H. GENETIC DELETION OF TRANSLOCATOR PROTEIN
EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC
MOUSE MODEL. Shock. 2023 Jan 1;59(1):82-90. doi: 10.1097/SHK.0000000000002030.
Epub 2022 Nov 3. PMID: 36703279.
4: Hashimoto K, Yamawaki Y, Yamaoka K, Yoshida T, Okada K, Tan W, Yamasaki M,
Matsumoto-Makidono Y, Kubo R, Nakayama H, Kataoka T, Kanematsu T, Watanabe M,
Okamoto Y, Morinobu S, Aizawa H, Yamawaki S. Spike firing attenuation of
serotonin neurons in learned helplessness rats is reversed by ketamine. Brain
Commun. 2021 Dec 1;3(4):fcab285. doi: 10.1093/braincomms/fcab285. PMID:
34939032; PMCID: PMC8688795.
5: Zhu M, Kasaragod DK, Kikutani K, Taguchi K, Aizawa H. A Novel
Microcontroller-Based System for the Wheel-Running Activity in Mice. eNeuro.
2021 Nov 22;8(6):ENEURO.0260-21.2021. doi: 10.1523/ENEURO.0260-21.2021. PMID:
34479979; PMCID: PMC8609968.
6: Giga H, Ji B, Kikutani K, Fukuda S, Kitajima T, Katsumata S, Matsumata M,
Suhara T, Yamawaki S, Shime N, Hosokawa K, Aizawa H. Pharmacological and Genetic
Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in
Murine Endotoxemia Model. Shock. 2021 Jul 1;56(1):142-149. doi:
10.1097/SHK.0000000000001703. PMID: 33351449.
7: Ito H, Nozaki K, Sakimura K, Abe M, Yamawaki S, Aizawa H. Activation of
proprotein convertase in the mouse habenula causes depressive-like behaviors
through remodeling of extracellular matrix. Neuropsychopharmacology. 2021
Jan;46(2):442-454. doi: 10.1038/s41386-020-00843-0. Epub 2020 Sep 17. PMID:
32942293; PMCID: PMC7852607.
8: Aizawa H, Sun W, Sugiyama K, Itou Y, Aida T, Cui W, Toyoda S, Terai H,
Yanagisawa M, Tanaka K. Glial glutamate transporter GLT-1 determines
susceptibility to spreading depression in the mouse cerebral cortex. Glia. 2020
Dec;68(12):2631-2642. doi: 10.1002/glia.23874. Epub 2020 Jun 25. PMID: 32585762.
9: Kikutani K, Giga H, Hosokawa K, Shime N, Aizawa H. Microglial translocator
protein and stressor-related disorder. Neurochem Int. 2020 Nov;140:104855. doi:
10.1016/j.neuint.2020.104855. Epub 2020 Sep 24. PMID: 32980493.
10: Cui W, Aida T, Ito H, Kobayashi K, Wada Y, Kato S, Nakano T, Zhu M, Isa K,
Kobayashi K, Isa T, Tanaka K, Aizawa H. Dopaminergic Signaling in the Nucleus
Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. J
Neurosci. 2020 Sep 16;40(38):7241-7254. doi: 10.1523/JNEUROSCI.0444-20.2020.
Epub 2020 Aug 26. PMID: 32847967; PMCID: PMC7534921.
11: Yoshino A, Okamoto Y, Sumiya Y, Okada G, Takamura M, Ichikawa N, Nakano T,
Shibasaki C, Aizawa H, Yamawaki Y, Kawakami K, Yokoyama S, Yoshimoto J, Yamawaki
S. Importance of the Habenula for Avoidance Learning Including Contextual Cues
in the Human Brain: A Preliminary fMRI Study. Front Hum Neurosci. 2020 May
12;14:165. doi: 10.3389/fnhum.2020.00165. PMID: 32477084; PMCID: PMC7235292.
12: Nozaki K, Ito H, Ohgidani M, Yamawaki Y, Sahin EH, Kitajima T, Katsumata S,
Yamawaki S, Kato TA, Aizawa H. Antidepressant effect of the translocator protein
antagonist ONO-2952 on mouse behaviors under chronic social defeat stress.
Neuropharmacology. 2020 Jan 1;162:107835. doi: 10.1016/j.neuropharm.2019.107835.
Epub 2019 Nov 1. PMID: 31682855.
13: Yamawaki Y, Shirawachi S, Mizokami A, Nozaki K, Ito H, Asano S, Oue K,
Aizawa H, Yamawaki S, Hirata M, Kanematsu T. Phospholipase C-related
catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic
inflammation-mediated anorexia in mice. Neurochem Int. 2019 Dec;131:104563. doi:
10.1016/j.neuint.2019.104563. Epub 2019 Oct 4. PMID: 31589911.
14: Aizawa H, Zhu M. Toward an understanding of the habenula's various roles in
human depression. Psychiatry Clin Neurosci. 2019 Oct;73(10):607-612. doi:
10.1111/pcn.12892. Epub 2019 Jun 18. PMID: 31131942.
15: Yoshino A, Aizawa H, Takamura M, Ichikawa N, Shibasaki C, Yamawaki Y,
Sasaoka T, Okamoto Y, Yamawaki S. [The Role of the Habenula in Depression: A
Review of the Human fMRI Studies]. Brain Nerve. 2018 Sep;70(9):1017-1023.
Japanese. doi: 10.11477/mf.1416201121. PMID: 30177579.
16: Sugimoto J, Tanaka M, Sugiyama K, Ito Y, Aizawa H, Soma M, Shimizu T, Mitani
A, Tanaka K. Region-specific deletions of the glutamate transporter GLT1
differentially affect seizure activity and neurodegeneration in mice. Glia. 2018
Apr;66(4):777-788. doi: 10.1002/glia.23281. Epub 2017 Dec 6. PMID: 29214672.
17: Yamawaki Y, Yoshioka N, Nozaki K, Ito H, Oda K, Harada K, Shirawachi S,
Asano S, Aizawa H, Yamawaki S, Kanematsu T, Akagi H. Sodium butyrate abolishes
lipopolysaccharide-induced depression-like behaviors and hippocampal microglial
activation in mice. Brain Res. 2018 Feb 1;1680:13-38. doi:
10.1016/j.brainres.2017.12.004. Epub 2017 Dec 8. PMID: 29229502.
18: Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H,
Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K. Alternative splicing in the
C-terminal tail of Cav2.1 is essential for preventing a neurological disease in
mice. Hum Mol Genet. 2017 Aug 15;26(16):3094-3104. doi: 10.1093/hmg/ddx193.
PMID: 28510727.
19: Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T,
Aizawa H, Yamamoto T, Tanaka K. Gene cassette knock-in in mammalian cells and
zygotes by enhanced MMEJ. BMC Genomics. 2016 Nov 28;17(1):979. doi:
10.1186/s12864-016-3331-9. PMID: 27894274; PMCID: PMC5126809.
20: Ishizu N, Yui D, Hebisawa A, Aizawa H, Cui W, Fujita Y, Hashimoto K, Ajioka
I, Mizusawa H, Yokota T, Watase K. Impaired striatal dopamine release in
homozygous Vps35 D620N knock-in mice. Hum Mol Genet. 2016 Oct
15;25(20):4507-4517. doi: 10.1093/hmg/ddw279. PMID: 28173004.
21: Ishii K, Kubo K, Endo T, Yoshida K, Benner S, Ito Y, Aizawa H, Aramaki M,
Yamanaka A, Tanaka K, Takata N, Tanaka KF, Mimura M, Tohyama C, Kakeyama M,
Nakajima K. Neuronal Heterotopias Affect the Activities of Distant Brain Areas
and Lead to Behavioral Deficits. J Neurosci. 2015 Sep 9;35(36):12432-45. doi:
10.1523/JNEUROSCI.3648-14.2015. PMID: 26354912; PMCID: PMC6605399.
22: Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui
W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M,
Götz M, Hirase H, Tanaka K. Astroglial glutamate transporter deficiency
increases synaptic excitability and leads to pathological repetitive behaviors
in mice. Neuropsychopharmacology. 2015 Jun;40(7):1569-79. doi:
10.1038/npp.2015.26. Epub 2015 Feb 9. PMID: 25662838; PMCID: PMC4915262.
23: Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R,
Ozawa K, Tanaka K, Aizawa H. Glial dysfunction in the mouse habenula causes
depressive-like behaviors and sleep disturbance. J Neurosci. 2014 Dec
3;34(49):16273-85. doi: 10.1523/JNEUROSCI.1465-14.2014. PMID: 25471567; PMCID:
PMC6608483.
24: Aizawa H, Cui W, Tanaka K, Okamoto H. Hyperactivation of the habenula as a
link between depression and sleep disturbance. Front Hum Neurosci. 2013 Dec
10;7:826. doi: 10.3389/fnhum.2013.00826. PMID: 24339810; PMCID: PMC3857532.
25: Isomura Y, Takekawa T, Harukuni R, Handa T, Aizawa H, Takada M, Fukai T.
Reward-modulated motor information in identified striatum neurons. J Neurosci.
2013 Jun 19;33(25):10209-20. doi: 10.1523/JNEUROSCI.0381-13.2013. PMID:
23785137; PMCID: PMC6618603.
26: Aizawa H, Yanagihara S, Kobayashi M, Niisato K, Takekawa T, Harukuni R,
McHugh TJ, Fukai T, Isomura Y, Okamoto H. The synchronous activity of lateral
habenular neurons is essential for regulating hippocampal theta oscillation. J
Neurosci. 2013 May 15;33(20):8909-21. doi: 10.1523/JNEUROSCI.4369-12.2013. PMID:
23678132; PMCID: PMC6618841.
27: Okamoto H, Aizawa H. Fear and anxiety regulation by conserved affective
circuits. Neuron. 2013 May 8;78(3):411-3. doi: 10.1016/j.neuron.2013.04.031.
PMID: 23664609.
28: Aizawa H, Kobayashi M, Tanaka S, Fukai T, Okamoto H. Molecular
characterization of the subnuclei in rat habenula. J Comp Neurol. 2012 Dec
15;520(18):4051-66. doi: 10.1002/cne.23167. PMID: 22700183.
29: Aizawa H, Amo R, Okamoto H. Phylogeny and ontogeny of the habenular
structure. Front Neurosci. 2011 Dec 21;5:138. doi: 10.3389/fnins.2011.00138.
PMID: 22203792; PMCID: PMC3244072.
30: Isomura Y, Harukuni R, Takekawa T, Aizawa H, Fukai T. Microcircuitry
coordination of cortical motor information in self-initiation of voluntary
movements. Nat Neurosci. 2009 Dec;12(12):1586-93. doi: 10.1038/nn.2431. Epub
2009 Nov 8. PMID: 19898469.
31: Soma M, Aizawa H, Ito Y, Maekawa M, Osumi N, Nakahira E, Okamoto H, Tanaka
K, Yuasa S. Development of the mouse amygdala as revealed by enhanced green
fluorescent protein gene transfer by means of in utero electroporation. J Comp
Neurol. 2009 Mar 1;513(1):113-28. doi: 10.1002/cne.21945. PMID: 19107806.
32: Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S, Nakajima D,
Nagase T, Ohara O, Koga H. Prediction of the coding sequences of mouse
homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse
KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA
clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb
28;10(1):35-48. doi: 10.1093/dnares/10.1.35. PMID: 12693553.
33: Yuasa S, Nakajima M, Aizawa H, Sahara N, Koizumi K, Sakai T, Usami M,
Kobayashi S, Kuroyanagi H, Mori H, Koseki H, Shirasawa T. Impaired cell cycle
control of neuronal precursor cells in the neocortical primordium of
presenilin-1-deficient mice. J Neurosci Res. 2002 Nov 1;70(3):501-13. doi:
10.1002/jnr.10430. PMID: 12391611.