PUBLICATION
Zebrafish foxi1 mediates otic placode formation and jaw development
- Authors
- Solomon, K.S., Kudoh, T., Dawid, I.B., and Fritz, A.
- ID
- ZDB-PUB-030606-1
- Date
- 2003
- Source
- Development (Cambridge, England) 130(5): 929-940 (Journal)
- Registered Authors
- Dawid, Igor B., Fritz, Andreas, Kudoh, Tetsuhiro, Solomon, Keely
- Keywords
- none
- MeSH Terms
-
- Neural Crest/cytology
- Neural Crest/physiology
- Forkhead Transcription Factors
- DNA-Binding Proteins/chemistry
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism*
- Animals
- In Situ Hybridization
- Nuclear Proteins*
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Amino Acid Sequence
- Base Sequence
- Gene Expression Regulation, Developmental
- Mutation
- Transcription Factors/chemistry
- Transcription Factors/genetics
- Transcription Factors/metabolism*
- Trans-Activators/genetics
- Trans-Activators/metabolism
- Molecular Sequence Data
- Zebrafish/anatomy & histology
- Zebrafish/embryology*
- Zebrafish/genetics
- Embryonic Structures/embryology
- Mandible/embryology
- Humans
- Ear/embryology
- Phenotype
- Paired Box Transcription Factors
- PubMed
- 12538519 Full text @ Development
Citation
Solomon, K.S., Kudoh, T., Dawid, I.B., and Fritz, A. (2003) Zebrafish foxi1 mediates otic placode formation and jaw development. Development (Cambridge, England). 130(5):929-940.
Abstract
The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within otic primordia. Here, we identify a mutation in zebrafish, hearsay, which disrupts the initiation of placode formation. We show that hearsay disrupts foxi1, a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi1 appears to be the earliest marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8, indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping