ZFIN Image: Powell et al., 2024, Fig. 4

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Figure Caption

Fig. 4 CACHD1 forms a ternary complex with FZD5 and LRP6.

(A) Cartoon representation of mouse CACHD1_ECD, [rainbow-colored from N terminus (blue) to C terminus (red)] in complex with mouse FZD5_CRD (cartoon and surface in teal) and human LRP6_P3E3P4E4 (cartoon and surface in salmon pink). The position of the four cache (C-1, -2, -3 and -4), VWA and FZD interaction (FZI) domains of CACHD1_ECD are indicated (PDB ID 8S7C). (B) Superimposed structures of the FZD8:WNT3 complex (PDB ID 6AHY) with the FZD5_CRD:CACHD1_ECD complex. WNT3 is shown as a violet cartoon tube with palmitoleic acid (PAM) as spheres. (C) Superimposed structures of the LRP6:DKK1-C complex (PDB ID 5FWW) with the CACHD1_ECD:LRP6_P3E3P4E4 complex. DKK1-C is shown as a magenta cartoon tube.

Acknowledgments

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