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Fig. 4 Cardiomyocytes differentiate normally in smarcc1a mutants. Whole-mount in situ hybridization depicts the expression of nkx2.5 (A, B) and myl7 (C, D) in the ALPM at 10 and 18 som, respectively. Dorsal views, anterior to the top. (A, B) The nkx2.5 expression domain in smarcc1a mutant embryos is indistinguishable from that of wild-type embryos. (C, D) smarcc1a mutants do not exhibit evident deficiencies in their populations of myl7-expressing differentiated cardiomyocytes. However, the morphogenesis of the medially migrating cardiomyocytes appears slightly delayed and disorganized in smarcc1a mutants