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Fig. 5 The Hippo signalling pathway might be involved in RNF213-related MMD pathogenesis, as shown through bioinformatics analyses. (A) Volcano plot showing 2633 differentially expressed genes (DEGs) between siNC- and siRNF213-treated human brain microvascular endothelial cell (HBMECs), including 1431 upregulated (red) and 1202 downregulated (blue) DEGs. (B) GO analysis indicated functions that were positively and negatively regulated by the top 100 RNF213-related DEGs. (C) Functional enrichment analysis of pathways significantly enriched in the RNF213-related DEGs. (D) Volcano plot showing 584 DEGs between intracranial aneurysm (IA) donor superficial temporal arteries and moyamoya disease (MMD) donor superficial temporal arteries, including 301 upregulated (red) and 283 downregulated (blue) DEGs. (E) GO analysis of functions that were positively and negatively regulated by the top 100 MMD-related DEGs. (F) Functional enrichment analysis of pathways significantly enriched in MMD-related DEGs.