ZFIN Image: Zhuang et al., 2022, Fig. 4

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Figure Caption

Fig. 4

hdac6 and hdac8 are necessary for the pronephros repair process. (A) In situ hybridization revealed an upregulation of hdac6 (upper panel) and hdac8 (lower panel) two hours after laser-induced injury. The arrow points to the injury site. (B) Depletion of zebrafish hdac6 by translation- (TBM) blocking morpholino oligonucleotides (MO) significantly reduced the percentage of embryos that repaired the pronephric tubule (Fisher’s exact test, two-tailed). Co-injection of hdac6 mRNA rescued the hdac6 TBM pronephros repair phenotype. (C) Depletion of hdac8 with translation-blocking morpholino oligonucleotides significantly reduced number of repaired pronephri. The group size is shown in brackets. Individual experiments with mean and standard deviation for each group are displayed. Significance was calculated with Fisher’s exact test (two-tailed).

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Acknowledgments

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