Gene
hdac6
- ID
- ZDB-GENE-030131-3232
- Name
- histone deacetylase 6
- Symbol
- hdac6 Nomenclature History
- Previous Names
-
- wu:fc31d02
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of tubulin deacetylation; and swimming behavior. Predicted to be part of histone deacetylase complex. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia and polycystic liver disease 1. Orthologous to human HDAC6 (histone deacetylase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia | Alliance | ?Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia | 300863 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001607 | Zinc finger, UBP-type |
| Domain | IPR023801 | Histone deacetylase domain |
| Family | IPR000286 | Histone deacetylase family |
| Family | IPR050284 | Histone deacetylase and polyamine deacetylase |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Ureohydrolase domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F8W4B7 | InterPro PDB | 1081 | |||||||
| UniProtKB:A7YT55 | InterPro PDB | 929 |
Interactions and Pathways
No data available
Plasmids