ZFIN Image: Elfatih et al., 2022, Figure 5

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Figure 5

Zebrafish LMNA model heart structure abnormalities. Modeling Qatar Genome Programme human LMNA cardiac variant produced abnormal heart chambers in LMNA zebrafish model. (A) Proportion of heart abnormalities, including valve defects and abnormal heart chamber shape in the four experimental groups. (B) LMNA zebrafish heart 3D structure at 72 hours post fertilization (hpf). Transgenic embryos (Tg:gata1: dsRed, cmlc2:eGFP), expressing red fluorescent red blood cells and green hearts) showing the abnormal cardiac chambers structure (Atrium: A, Ventricle: V). AV valve: Control (n = 3), lmna MO (n = 5), MO + LMNA^Variant (n = 14), and MO + LMNA^WT (n = 0). Ventricular shape: Control (n = 2), lmna MO (n = 14), MO + LMNA^Variant (n = 28), and MO + LMNA^WT (n = 5). Atrium shape: Control (n = 0), MO (n = 10), MO + LMNA^Variant (n = 16), and MO + LMNA^WT (n = 1).

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Acknowledgments

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