ZFIN Image: Zhang et al., 2021, FIGURE 1

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FIGURE 1

Figure 1. Knockout of ltv1 and craniofacial defects in ltv1^Δ14/Δ14 mutant. (A) The sequences flanking the deletion site in ltv1 mutants (ltv1^Δ7,14) are shown. The deleted nucleotides are denoted by dashes. In ltv1^Δ7/Δ7 mutant, 9 bp nucleotides are deleted and 2 bp nucleotides (red font) are inserted. (B) Two ltv1 mutant alleles (ltv1^Δ14 and ltv1^Δ7) harbor frameshift mutations that are predicted to give rise to truncated Ltv1 proteins as shown. (C) WISH using ltv1 antisense RNA probe at 3 dpf. (D,E) Representative images of ltv1^Δ14/Δ14 mutants and siblings at 3 and 5 dpf. (F) Alcian blue-labeled craniofacial cartilage in ventral view at 5 dpf. Abbreviations used: sb, swimming bladder; ib, intestinal bulb; y, yolk; m, Meckel’s; pq, palatoquadrate; ch, ceratohyal; cb, ceratobranchial.

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Acknowledgments

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