ZFIN Image: Rattka et al., 2021, Fig. 5

Image

Figure Caption

Fig. 5 (A,B) Lateral view of Cx43-deficient (B) and control-injected embryos (A) at 72 hpf. Cx43 deficiency results in development of a large pericardial edema at 72 hpf (B, black arrow) while the controls don't display cardiac abnormalities (A). (C) 47% (47/99) MO-cx43_ATG- injected embryos displayed a heart failure and arrhythmia phenotype. Embryos with pericardial edema, bradycardia, and impaired contractility were counted as affected. (D) Efficacy of morpholino-mediated knockdown experiments was confirmed by Western Blot analysis. Images (A, B) have been cropped. C: Assessment of significance by chi-squared test. ****p < 0.0001.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Journal of Molecular and Cellular Cardiology, 155, Rattka, M., Westphal, S., Gahr, B.M., Just, S., Rottbauer, W., Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish, 25-35, Copyright (2021) with permission from Elsevier. Full text @ J. Mol. Cell. Cardiol.