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Fig. 2 (A,B) Fractional shortening of spen morphants and controls at 48 hpf and 60 hpf. Impairment of ventricular fractional shortening in Spen-deficient embryos starts at 48 hpf (12 [10%–15%] vs. 43 [41%–53%], n = 15) and becomes more severe at 60 hpf (3 [1%–5%] vs. 52 [44%–65%], n = 15). (C,D) Heart rate (in beats per minute) is severely reduced in spen morphants compared to control-injected fish at 48 hpf (49 ± 15 vs. 150 ± 15, n = 15) and 60 hpf (58 ± 16 vs. 166 ± 12, n = 15). A–D: Assessment of significance by Wilcoxon-Mann-Whitney test. ****p < 0.0001.
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Reprinted from Journal of Molecular and Cellular Cardiology, 155, Rattka, M., Westphal, S., Gahr, B.M., Just, S., Rottbauer, W., Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish, 25-35, Copyright (2021) with permission from Elsevier. Full text @ J. Mol. Cell. Cardiol.