ZFIN Image: Rohrer et al., 2021, Figure 1

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Figure Caption

Figure 1 Histological and TEM analysis of RPE and retinas of wild-type and exoc5 mutant zebrafish larvae. (A) In systemic exoc5 homozygous mutants (exoc5−/−), the photoreceptor outer segments (OS) were shorter compared to wild-type (WT) siblings. (B) Ultrastructural analysis of WT and exoc5−/− mutant RPE using transmission electron microscopy indicate reduced levels of melanosomes in the mutant fish RPE. (C) WT photoreceptors showed tightly stacked disk membranes, while in exoc5−/− mutants, only remnants of outer segments (OS) could be observed. Please note the apparent formation of ectosomes at the base of the mutant photoreceptor OS. Scale bars = 2 μm (B), 800 nm (C). OS, outer segments; ONL, outer nuclear layer; RPE, retinal pigmented epithelium; INL, inner nuclear layer; GCL, ganglion cell layer.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.