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Fig. 1 Zebrafish aqp0 mutant lens growth. Zebrafish standard length (A) and lens diameter (B) as a function of age (dpf) for WT, aqp0a−/−, aqp0b−/−, and double aqp0a−/−/aqp0b−/− mutants. WT and aqp0b−/− standard length growth plateaued at ∼24 mm after ∼350 dpf (A, red and blue); in aqp0a−/−, at ∼23 mm after ∼350 dpf (A, green). The double mutant standard length plateaued at ∼20 mm after the age of ∼180 dpf (A, black). Lens growth in WT and aqp0b−/− plateaued at ∼710 µm (B, red and blue), which corresponds to ∼500 dpf; there was no plateau for samples from aqp0a−/− mutants with a maximum attained value of 900 µm at 900 dpf (B, green), and lens growth plateaued at ∼640 µm in double homozygotes after ∼230 dpf (B, black).