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Figure 1 Zebrafish eif2b3 knockout model for VWM disease. (A) Visualization of myelination using Tg (mbp:mGFP) crossed with eif2b3−/− zebrafish at 5 dpf. Myelination defects in eif2b3−/− which recapitulate phenotypes of VWM disease. (B) Whole-mount in situ hybridization with myelin development markers, mbp, olig2, and nestin in eif2b3−/− zebrafish. mbp, myelin basic protein; oilg2, oligodendrocyte transcription factor; nestin, early neural stem/progenitor cell marker. Arrow indicates ectopic expression of nestin in the midbrain region. R, retina.
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Full text @ Int. J. Mol. Sci.