ZFIN Image: Jung et al., 2021, Figure 5.

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Figure Caption

Figure 5.

Inhibition of SHH signaling by cyclopamine decreased the level of trim46a transcripts in dose-dependent manners. (A–D) WISH analysis using foxa2 specific probe detected foxa2 transcripts in the midbrain at 24 hpf. Level of foxa2 transcripts decreased in the embryos treated with cyclopamine versus the control. (E–H) WISH analysis of cyclopamine-treated embryos using trim46a as a probe. Cyclopamine caused reduction in the level of trim46a transcripts in comparison to those of EtOH control in dose-dependent manners. (I) Quantification of foxa2 transcripts in the ZLI, and trim46a transcripts in the forebrain, midbrain and cerebellum at 24 hpf using ImageJ software. CCP, cyclopamine. (A–H) Scale bars: 50 μm.

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Acknowledgments

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