Fig. 9

Fig. 9 Fig. 9. A proposed model describing the role of Cdx1b in the regulation of epithalamic laterality. A Cdx1b may activate and maintain expression of ndr2 and lft1 in the left dorsal diencephalon during 19–22 ​s, which is essential for subsequent left-sided parapineal migration and asymmetry of habenular nuclei at 72 hpf. Percentages of ndr2 and lft1 expression in the left dorsal diencephalon and left-bias expression of kctd12.1 in the habenula are indicated in wild-type embryos. B In MZcdx1b−/− mutant embryos, reduced and absent expression of ndr2, lft1 and pitx2c in the left dorsal diencephalon results in aberrant parapineal migration and habenular laterality. Percentages of absent expression of ndr2 and lft1 in the dorsal diencephalon as well as left-bias or right-bias expression of kctd12.1 in the habenula are indicated in MZcdx1b−/− mutant embryos.