ZFIN Image: Brock et al., 2019, Fig. 4

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Fig. 4

ESAB (epithelial stem cell-derived apoptotic body)-delivered Wnt8a is required for apoptosis-induced stem cell division. a–f Maximum intensity projections of confocal images for bromodeoxyuridine (BrdU) (green) and p63 (magenta) after perturbation of Wnt8a signaling (a–c), and in combination with induction of apoptosis (d–f) (scale = 50 µm). g Mean number of BrdU-positive cells from individual larvae after perturbation of Wnt8a (n = 9) and in combination with induced apoptosis (n = 10). h Quantitative analysis of ESAB production from controls (n = 35) and after treatment with apoptosis inhibitor (AI) (n = 20), the Wnt inhibitor IWR (n = 10) or overexpression of Wnt8a (n = 13). Data are represented as mean ± sd; ****p < 0.0001. One-way analysis of variance (ANOVA) with Dunnett’s mutiple comparisons test (g, h)

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Acknowledgments

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