ZFIN Image: Kefalos et al., 2019, Figure 4

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Figure Caption

Figure 4

Zebrafish adult valves retain the ability to regenerate through Notch signaling reactivation. (A–D) Z-stack projection of a wt untreated adult valve of an hspGFFDMC73A/UAS-E1b:NfsB-mCherry transgenic fish stained with elastin2. (E–H) Valvular damage of an adult heart of a hspGFFDMC73A/UAS-E1b:NfsB-mCherry transgenic immediately after completion of the MTZ treatment (n = 10). (I–L) Regenerating valve 15 days post chemogenetic valve cell ablation (n = 13). (M–P) Inhibition of regeneration process in the heart of an adult heart of a hspGFFDMC73A/UAS-E1b:NfsB-mCherry transgenic after MTZ treatment and 15 day treatment with DAPT (n = 12). Scale bars: 50 micron.

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